In light of the findings of ERβ in sustaining E-cadherin expression and preventing an epithelial-mesenchymal transition (EMP) in PCa cells by sequestering Snail 1 in the cytoplasm [130], downregulation of this receptor expression in grade 4/5 carcinomas provokes acquisition of mesenchymal characteristics and aggressive behaviors of the cells that are associated with high-grade PCa. This evidence concerns the gene ESR2 and carcinoma.