Later, Bonkhoff et al. detected ERα but not ERβ transcripts in 11% of high-grade prostatic intraepithelial neoplasia, 43% of Gleason grade 4 PCa, and 61% of grade 5 cancer as well as 94% of recurrent adenocarcinoma after hormonal therapy [114]. Here, ESR1 is linked to posterior cortical atrophy.