ZEB1 and hepatocellular carcinoma: Li et al. discovered in HCC cells that overexpression of ZEB1-AS1, greatly inducing the expression and activity of ZEB1, could lead to a decreased protein level of E-cadherin, an epithelial marker, as well as an increased expression of mesenchymal markers, such as Vimentin, N-cadherin, and Fibronectin [19].