Recently, T Li and colleagues found that lncRNA ZEB1-AS1—a non-coding antisense transcript that originates from the promoters of ZEB1—was highly expressed in hepatocellular carcinoma, especially in metastatic liver tumor tissues, and related to poor outcome of HCC patients [19], with its similar role in esophageal squamous cell carcinoma (ESCC) having also been observed by Wang et al. [20]. The gene discussed is ZEB1; the disease is esophageal squamous cell carcinoma.