BAX and central nervous system cancer: Additionally, apoptosis markers were also examined, as shown in Figure 6C, the expression levels of Bax were dramatically increased, while Bcl-2 expression was greatly reduced after ZEB1-AS1-siRNA transfection, demonstrating that the overexpression of ZEB1-AS1 probably played a crucial role in the regulation of the proliferation, apoptosis, migration, and invasion of human glioma cells.