MTOR and cancer: Therefore, we designed this study to determine the safety, maximum tolerated dose (MTD) and recommended phase II dose (RP2D), and dose-limiting toxicities (DLTs) of the combination of the mTOR inhibitor sirolimus (1 mg-5 mg PO daily, q 28 days) and the HDAC inhibitor vorinostat (100 mg-400 mg PO daily, q 28 days) in patients with advanced cancer.