HLA-E and neoplasm: The increased HLA-E expression has clinical relevance, since it could be correlated to tumor progression, metastasis formation and reduced survival of patients in some tumor entities, e.g. in laryngeal carcinoma [14], mammary carcinoma [15], small cell lung cancer [16], pancreatic cancer [17] ovarian carcinoma [11] and in colorectal carcinoma [18, 19].