The non-classical HLA-E mRNA is detected in all nucleated cells, while HLA-E protein is only ubiquitously expressed at low levels on the cell surface of most tissues and presents peptides derived from the conserved leader sequences of HLA-A, - B, -C and –G antigens to HLA-E-restricted immune effector cells demonstrating its importance for anti-tumor response [4, 9, 10]. This evidence concerns the gene HLA-E and neoplasm.