This was in line with the impaired CD94/NKG2A-dependent NK cell-mediated cytolysis of interferon (IFN)-γ-treated acute myeloid leukemia (AML) cells by NK cells [21] due to the IFN-γ-mediated upregulation of HLA-E on the cell surface. The gene discussed is HLA-E; the disease is acute myeloid leukemia.