Then, in differentiating advanced-stage renal fibrosis (IF/TA 3), the AUC-ROC of serum HE4 was 0.97 (95% CI, 0.95-0.99) with a sensitivity and specificity at 98.0 and 86.8, respectively (cut-off value was 294 pmol/L), higher than that of serum creatinine (0.93, 95% CI, 0.90-0.96) with a sensitivity and specificity at 84.0 % and 91.2 %, respectively (Figure 2D). The gene discussed is WFDC2; the disease is renal fibrosis.