CD274 and pancreatic ductal adenocarcinoma: Finally, we found a correlation between the PDL1 status and a recent transcriptional classification of pancreatic ductal carcinoma [42]: 56% of PDL1-up tumors were in the squamous subtype, and PDL1 mRNA was up-regulated in the squamous subtype versus each other subtype (pancreatic progenitor; immunogenic; and aberrantly differentiated endocrine exocrine).