Major actors of leukocyte activation (CD2, CD3D, CD3E, CD3G, CD4, CD5, CD8A, CD8B, CD27, CD28, CD38, CD40LG, CD80, CD86, CD226, CD247, HLA-DOA, HLA-DRA, KLRK1, TNFSF4, TNFSF14, TNFRSF8, IL2RA, IL7R, IL11, IL12RB1, IL12RB2, IL21R, IL31RA, IFNG, IKZF1, JAK2, PIK3CG, EOMES, RORA, TBX21...) were also positively correlated with PDL1 expression, attesting of a strong recruitment and tumor infiltration by T-cells in the “PDL1-up” group. The gene discussed is CD40LG; the disease is neoplasm.