First, compared with the control group, the GATA3-knockdown PTCL cells had lower levels of TH2-associated cytokines (IL4, IL5, and IL13) and VEGFA. IL-4 and IL-13 are inflammatory cytokines and may elicit or aggravate the “cytokine storm,” leading to hemophagocytic syndrome in the bone marrow and elevated serum ferritin levels. Here, IL4 is linked to hemophagocytic syndrome.