First, compared with the control group, the GATA3-knockdown PTCL cells had lower levels of TH2-associated cytokines (IL4, IL5, and IL13) and VEGFA. IL-4 and IL-13 are inflammatory cytokines and may elicit or aggravate the “cytokine storm,” leading to hemophagocytic syndrome in the bone marrow and elevated serum ferritin levels. This evidence concerns the gene IL13 and mature T-cell and NK-cell non-Hodgkin lymphoma.