Here we raise two hypotheses: 1) Because distinct cellular origins can cause vast differences in OS, GATA3+ tumor cells may indicate a cellular origin of TH2 lymphocytes, or 2) The transcription factor GATA3 may directly increase lymphoma cell malignancy through the up- or down-regulation of cytokine transcription or the activation of signal transduction pathways. This evidence concerns the gene GATA3 and lymphoma.