MCF10DCIS.COM cells are suggested to be a unique model to study DCIS as well as the role of factors to regulate the progression to invasive breast cancer because they expressed a high level of basal markers (CD44 and CD49f), a low level of luminal markers (CD24 and MUC-1) and putative BCSC markers (ALDH1) and result in basal-like DCIS with high similarities to human DCIS samples [28,34,35]. This evidence concerns the gene CD44 and ductal breast carcinoma in situ.