The high expression of lipogenic genes, such as sterol regulatory element-binding proteins (SREBPs), fatty acid synthase (FAS) and acetyl-CoA carboxylase 1 (ACC-1), appears early in oncogenesis, and lipid accumulation confers cell survival in epithelial stem-like cells in DCIS and promotes the transition of DCIS to invasive cancer [12,18]. The gene discussed is FASN; the disease is ductal breast carcinoma in situ.