When MetS was diagnosed using the full set of 5 criteria from the harmonised guidelines [2] (S1 Table), it was observed that in women with MetS both leg fat (14.8 ± 4.31 vs. 13.5 ± 4.72 kg; p<0.0005) and leptin (31.1 [18.6, 45.9] vs. 22.7 [13.1, 40.5]; p<0.0005) were significantly higher than in subjects without MetS. Here, LEP is linked to metabolic syndrome.