Next, we inquired the expression status of FPs in intestinal adenomas developed in the EKAREV mice crossed with ApcΔ716 mice (ApcΔ716), which have a truncation mutation in the Apc gene and serve as a model of human familial adenomatous polyposis (FAP) [19], as colorectal tumor incidence significantly increases with age. Here, APC is linked to colorectal neoplasm.