TGFB1 and neoplasm: A number of agents that interfere with TGF-β signalling are being clinically evaluated in the context of fibrosis and tumour treatment [68, 69], including neutralizing antibodies that abolish ligand receptor interactions, recombinant Fc-fusion proteins containing receptor ectodomains to sequester TGF-β, small molecule inhibitors of the TGF-β receptor kinases, and antisense oligonucleotides that reduce TGF-β expression.