SMC1A and B-cell chronic lymphocytic leukemia: The ratios of phosphorylated to total SMC1 and KAP1 from 46 CLL samples were analyzed by the normal mixture model-based clustering method.14 This determined that the cutoff numbers individually for both SMC1 and KAP1 to define ATM function deficiency were 21% and 55%, respectively, relative to the Pool value (Supplementary Figures 3A and B).