Recent work also suggests that SK2 can play a role in increasing telomerase activity [26], promoting the upregulation of c-Myc via regulation of HDAC1/2 [20], and facilitating the activation of ezrin-radixin-moesin proteins to promote EGF-induced cancer cell invasion [27], all of which may contribute to cancer development and progression. The gene discussed is HDAC1; the disease is cancer.