LDHA and posterior cortical atrophy: Upon siRNA-mediated knockdown of HIF-1α (Supplementary Figure 12C), expression of CA9, PDK1, LDHA and ENO2 was significantly reduced (Supplementary Figure 12D-12G), further underscoring the importance of HIF-1α signaling in marrow adipocyte-driven metabolic adaptation of PCa tumors in bone.