It is noteworthy that the expression of tumor-derived monoacyl glycerol lipase (MAGL), a lipase previously implicated in prostate cancer progression [62, 63], was also induced in response to adipocytes and persisted upon inhibition of adipocyte ATGL with Atglistatin, suggesting an additional possible compensatory mechanism in tumor cells that might be contributing to the adipocyte-driven metabolic phenotype (Supplementary Figure 10A). This evidence concerns the gene PNPLA2 and neoplasm.