BRCA1 and cancer: Studies examining cancer risk in BRCA1/2 mutation positive women have shown that approximately 50% of these women develop breast or ovarian cancer by the age of 70 years, but approximately 50% of these patients even in their late 80′s don't develop these cancers [32], suggesting that in addition to genetic changes, other factors, such as lifestyle, influence the risk of developing reproductive cancers [13, 33].