Not surprisingly, we observed increased PDGFA protein levels in Hep3B and MHCC-97H cells with ectopic over-expressed Nrf2, while PDGFA was decreased in MHCC-97H and SMMC-7721 cells with Nrf2 knockdown, indicating Nrf2 was involved in regulating the proliferative activity of HCC cells by increasing PDGFA expression level (Figure 3A and 3B). The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.