ST6GAL1 and colon adenocarcinoma: Moreover, it has been shown that the β1 integrins of colon adenocarcinoma cells carry higher levels of α2,6 linked sialic acid and that ST6Gal-I-mediated β1 integrin hypersialylation contributes to colon adenocarcinoma cell adhesion and migration, which indicates that α2,6-sialylation enhances β1 integrin function [38].