Also, mutation of PP2A subunits or decreased phosphatase activity of PP2A has been found in a variety of diseases including Alzheimer's disease, solid tumors and hematological malignancies [14–18], and the enhanced PP2A activity has also been found to be correlated with type II diabetes, inflammatory lung diseases like asthma and chronic obstructive pulmonary disease, and heart failure [19, 20]. The gene discussed is PTPA; the disease is early-onset autosomal dominant Alzheimer disease.