Importantly, patients with viral hepatitis or cirrhosis rarely express TLR7; (2) TLR7 activation is involved with marked increase in tumor cell proliferation and migration; (3) lipid rafts are positively associated with enhanced TLR7 signaling in HCC; (4) an increase in lipid raft content of HCC is likely attributable to a striking increase in cholesterol accumulation; (5) downstream NFκB pathway is involved with enhanced raft-associated TLR7 signaling in HCC. The gene discussed is TLR7; the disease is hepatocellular carcinoma.