To assess whether there is an association between eIF4E expression and chemotherapeutic response in ESCC patients, we next performed an escalating-dose experiment in EC9706 cells to examine the role of eIF4E in tumor cell chemosensitivity, according to the chemosensitivity to DDP in different ESCC cell lines (Supplementary Figure S4). The gene discussed is EIF4E; the disease is esophageal squamous cell carcinoma.