The present study have clarified the oncogenic role of eIF4E in ESCC, and confirmed that the weak mRNAs including C-myc, Cyclin D1, Bcl-2, Survivin, FGF-2, VEGF, and MMP-9 were regulated by eIF4E in ESCC cell line. The gene discussed is EIF4E; the disease is esophageal squamous cell carcinoma.