From the COSMIC and International Genome Cancer Consortium (http://dcc.icgc.org/) databases, recurrence of NKAIN2 mutation has been detected in breast (4/1233 samples), endometrioid (4/494), clear cell renal cell (2/878), lung squamous cell (4/531) and bladder (2/327) carcinomas, lung (7/639), esophagus (2/151) and stomach (6/338) adenocarcinomas, as well as skin malignant melanoma (13/526). The gene discussed is NKAIN2; the disease is carcinoma.