To explore whether prototypic ferroptosis-inducing compounds such as RSL3 and Erastin modulate Smac mimetic-induced cell death in ALL cells, we tested the antileukemic activity of the bivalent Smac mimetic BV6 that antagonizes cellular Inhibitor of Apoptosis (cIAP) and x-linked Inhibitor of Apoptosis (XIAP) proteins [14] together with RSL3 and Erastin that were recently described as two prototypic ferroptosis-inducing compounds [12]. The gene discussed is XIAP; the disease is acute lymphoblastic leukemia.