HK2 and glioblastoma: Compared to normal brain, HK1 was significantly down regulated in all GBM subtypes by an average of 4 fold (Supplementary Figure S1C, ***p < 0.001), while HK2 was significantly up-regulated by an average of 5 fold in all subtypes of GBM (Supplementary Figure S1D, ***p < 0.001).