TP53 and esophageal squamous cell carcinoma: The absence of cell death after the knockdown of UBE2C in TE-1 and TE-13 cells could be related with the absence of the apoptotic pathway mediated by TP53 whose loss represents the most frequent molecular alteration in esophageal carcinogenesis [32], and is also present in the ESCC cell lines used in this study [33, 34].