Previous studies indicate that the XPG rs2296147T>C polymorphism is suspected to have relationship with the clinical outcomes of cancer patients, such as colorectal cancer (CRC) [8–11], epithelial ovarian cancer (EOC) [12, 13], head and neck cancer(HNC) [14], non-small cell lung cancer (NSCLC) [15–19], gastric cancer (GC) [20] and osteosarcoma (OC) [21, 22]. The gene discussed is ERCC5; the disease is cancer.