NFATC1 and chronic kidney disease: Indeed, in animal models, salt sensitivity is tightly linked with a blunted tubuloglomerular feedback (TGF) or impaired increase in GFR after salt loading.50, 51, 52, 53 Consistent with this, we demonstrated that renal mRNA expression of Nfatc1 and Rgs14 in a salt-sensitive mouse model was reduced after exposure to a high-salt diet and induced CKD.