Given the reported involvement of NF-κB in regulating inflammatory responses in the CF airways and other tissues, we hypothesize that CFTR regulates NF-κB activity through β-catenin pathway, dysfunction of which may lead to aberrant activation of NF-κB/COX-2/PGE2 cascade and exaggerated inflammatory response observed in CF intestine. This evidence concerns the gene CFTR and cystic fibrosis.