Given the importance of Wnt/β-catenin pathway in many physiological and pathological conditions, the presently demonstrated critical role of CFTR in regulating β-catenin signaling provides novel insights into the physiological function of CFTR and pathogenesis of CF-related diseases in addition to the NF-κB-mediated intestinal inflammation seen in CF. The gene discussed is NFKB1; the disease is cystic fibrosis.