In general, downregulation of ZEB1, RECK, TGFBR2 and BMPR2, as well as upregulation of CDK4, CCNE2, EZH2 and DNMT1 has been shown in lung adenocarcinoma and/or squamous cell carcinoma [26–32]. The gene discussed is CCNE2; the disease is lung adenocarcinoma.