CDK4 and neoplasm: The resulting interaction network with changes in mRNA abundance associated with changes of miRNA abundance contains 12 target genes including CD44, ZEB1, ZEB2, BMPR2, RECK, TGFBR2, PURA and KAT2B as correctly predicted down-regulated genes, and DNMT1, CCNE2, CDK4, and EZH2 as correctly predicted up-regulated genes in tumor tissue.