In general, downregulation of ZEB1, RECK, TGFBR2 and BMPR2, as well as upregulation of CDK4, CCNE2, EZH2 and DNMT1 has been shown in lung adenocarcinoma and/or squamous cell carcinoma [26–32]. Here, TGFBR2 is linked to squamous cell carcinoma.