Since LASP1 overexpression and worse patient outcome has been described in several cancer entities, we next checked whether LASP1 knockdown is also affecting MMP expression in the primary, non-invasive, BT-20 breast cancer cell line as well as in T24 bladder and LNCaP prostate cancer cell lines, known to express high levels of LASP1 [19, 28]. Here, LASP1 is linked to Familial prostate cancer.