In the present study, we investigated the effect of LASP1 on expression, secretion and activation of MMPs in MDA-MB-231 breast cancer cells since LASP1 overexpression could promote MMP activity in podosomes and invadopodia and hence, by analogy to its observed role in podosomes of macrophages, modulate matrix degradation and invasive potential of aggressive tumors. This evidence concerns the gene LASP1 and breast cancer.