KLK3 and posterior cortical atrophy: Pokorny, et al. found in a prospective study that when multiphasic magnetic resonance imaging and magnetic resonance-guided biopsy was added for PCa detection in men with elevated PSA, the need for biopsy was decreased by 51%, the diagnosis of low-risk PCa decreased by 89.4%, and the detection of intermediate and high-risk PCa increased by 17.7%, all when compared to transrectal ultrasound-guided biopsy.