Metformin, a compound derived from the French Lilac (G. officinalis) and chemically known as N,N-Dimethylimidodicarbonimidic diamide, is a guanidine-based hypoglycemic agent commonly used in treating patients with type II diabetes (T2D; Witters, 2001) by inhibiting hepatic gluconeogenesis and decreasing insulin levels (Hundal et al., 2000; Zhou et al., 2001). Here, INS is linked to type 2 diabetes mellitus.