ATP7A and nutritional disorder: Iron deficiency in the intestinal epithelial cells leads to the upregulation of the ATP7A gene and iron-homeostasis related genes: the cell surface ferrireductase gene Dtcyb, the iron ion transporter gene DMT1 and the basolateral iron exporter ferroportin gene (FPN) (Xie and Collins, 2011, Xie and Collins, 2013).