Using the combination of FGFR3 mutation and methylation, the detection of recurrence was significantly increased with 96.4 % pTa, 100 % pT1, 100 % CIS, 50.0 % other tumor stages, 93.6 %/96.0 % low-/high-grade tumors. The gene discussed is FGFR3; the disease is in situ carcinoma.