Taking into account the influence of multiple TLR4 and TLR9 SNPs on the development of congenital CMV infection, this study showed that GCA haplotype at rs4986790, rs4986791, and rs352140, respectively, was significantly associated with CMV congenital infection (odds ratio [OR] 6.5 × 1012, P ≤ 0.0001), and that ACA haplotype was more frequent among symptomatic CMV-infected cases than among asymptomatic cases (P ≤ 0.0001) (20). This evidence concerns the gene TLR4 and cytomegalovirus infection.