Genes involved in the regulation of neurogenesis (e.g., KIT, DLX1, DLX2, ID4, NEUROD1, BARHL2 and IRX3) were more significantly dysregulated in iPSCs-derived neurons and fetal brains derived from individuals with DS as well as in the Ts65Dn mouse model, but they were not significantly affected in the Ts1Cje and Dp16 mouse models. This evidence concerns the gene IRX3 and Dravet syndrome.