Meanwhile, these target genes also participated in the regulation of breast cancer and estrogen-related cancer signalings, such as HER-2 Signaling in Breast Cancer, Hereditary Breast Cancer Signaling, Breast Cancer Regulation by Stathmin1, Estrogen Receptor Signaling, Estrogen-Dependent Breast Cancer Signaling, Endometrial Cancer Signaling and so on. Here, ESR1 is linked to cancer.