PLCZ1 and familial thoracic aortic aneurysm and aortic dissection: When we filtered variants that were present in all three exome-sequenced afflicted individuals (II:2, II:3, and II:8) but absent from the >1000 exomes present in our local database, we identified sequence variants in SEMA4A, PLCZ1, FBLN5, SPG11, and RANBP2. None of these genes have been previously associated with FTAAD.