Interestingly, depletion of enzymes in oxidative PPP, i.e. G6PD, PGLS (6-phosphogluconolactonase), and PGD, dramatically abrogated the proliferation of HL-60, a human promyelocytic leukaemia cell line (Fig. 1b–d and s1a). The gene discussed is PGD; the disease is acute promyelocytic leukemia.