Previous study suggest that CK8 deficient mice develop spontaneous chronic T helper type 2 colitis (Th2 colitis)20 and the colonic inflammation in the CK8−/− mice was prevented by administering antibiotics (vancomycin and imipenem), indicating a possible role of luminal bacteria in triggering colitis in mice with absence of CK8. This evidence concerns the gene KRT8 and inflammatory response.