Of particular relevance to the current study and the mechanism of CNS phenotypes in CMT1X is the Cx32/Cx43 double KO model, which revealed that in the absence of Cx32 GJs (as in CMT1X patients) oligodendrocytes depend exclusively on Cx43/Cx47 GJs. Here, GJB1 is linked to X-linked Charcot-Marie-Tooth disease type 1.