Thus, it is plausible to hypothesize that in CMT1X patients, in whom oligodendrocyte GJ connectivity depends only on Cx43/Cx47 GJs, downregulation of Cx43 as part of an astrocyte reaction to inflammatory or metabolic stress will disrupt Cx47 in oligodendrocytes and lead to transient encephalopathy. This evidence concerns the gene GJC2 and X-linked Charcot-Marie-Tooth disease type 1.