GJB1 and X-linked Charcot-Marie-Tooth disease type 1: To further clarify the cellular mechanisms underlying the CNS phenotypes in patients with CMT1X, we used a model of systemic inflammation induced by lipopolysaccharide (LPS) injection comparing wild-type (WT) mice, Cx32 knockout (KO) mice, and Cx32 KO expressing the T55I mutant of Cx32 (KO T55I).