LTBP4 and cutis laxa with severe pulmonary, gastrointestinal and urinary anomalies: Contrary to Ltbp4−/− mice, which resemble the features of ARCL1C, Ltbp4S−/− mice develop a milder form of ARCL1C with a later onset of symptoms and prolonged survival (Bultmann-Mellin et al., 2015).