In contrast, Pdx1-Cre-K-MADM-p53 mice developed the full spectrum of pancreatic tumour progression from low-grade (Fig. 5b) and high-grade PanINs (Fig. 5c) to advanced PDAC (Fig. 5d) and occasionally distant metastases (Fig. 5e,f). This evidence concerns the gene TP53 and pancreatic neoplasm.