TP53 and lung adenoma: By comparing LSL-KrasG12D/KrasWT; p53WT/WT and LSL-KrasG12D/KrasWT; p53flox/flox mice infected with inhaled adenovirus carrying Cre recombinase, our laboratory revealed a role of p53 in limiting tumour progression from low-grade lung adenomas to advanced adenocarcinomas11.