In present study, we analyzed the role of GRAMD1A in HCC prognosis and progression, and found GRAMD1A was upregulated in HCC tissues, GRAMD1A expression was significantly positively correlated with pathologic differentiation and survival state, patients with high GRAMD1A had poor outcome, Further analysis revealed GRAMD1A was an independent prognostic factor for HCC patients. This evidence concerns the gene GRAMD1A and hepatocellular carcinoma.