It was reported that the increase in tumour antigen CA15-3 and antibodies for tumour protein markers c-erbB2, CA-125 and P53 in saliva can also be considered salivary biomarkers for cancers of the oral cavity and other sites.17 Further studies showed that hyaluronidase, IL-6 and IL-8 might be potential biomarkers for patients presenting with head and neck squamous cell carcinoma (HNSCC). The gene discussed is TP53; the disease is head and neck squamous cell carcinoma.