TNF and neoplasm: Of note, the levels of IL-10 and IL-13 were significantly increased, whereas the level of IL-1RA was the highest in poorly differentiated OSCC lesions compared with well- and moderately differentiated OSCC lesions.19 A similar study found that the levels of TNF-α were higher in moderately and poorly differentiated tumours than in well-differentiated and stage IV tumours.