CTNNB1 and cancer: In this study, we applied systematic bioinformatics analyses on both N- and C-terminal tails of beta-Catenin, identified multiple functional motifs, characterized the conserved sequential segments, discovered the pattern of interactions between beta-Catenin and its partners, revealed the correlation between cancer-associated mutations and functional motifs, and proposed possible regulatory mechanisms of flexible tails on the function of beta-Catenin.