On the other hand, several other studies suggested that MTHFR C677T polymorphism itself is not a major risk factor [10, 27] as these studies could not find any significant association with susceptibility risk of POAG in Japanese [28], Austrian [16], Swedish [18], Pakistani [6], Iranian [29], Mexican [30] and Greek populations [13]. The gene discussed is MTHFR; the disease is open-angle glaucoma.