The inclusion of patients with longstanding T1D (mean duration: 21 years), often treated by medication acting on the Renin-Angiotensin System, was logical to study “hard” complications as MVE, but it may have precluded the finding of earlier events such as microalbuminuria as reported in recent and well-controlled patients with T2D [10]: the incidence of microalbuminuria is known to naturally decline after 20 years of diabetes [36]. The gene discussed is REN; the disease is diabetes mellitus.