The mammalian transcription factor, Hypoxia-inducible factor-1α (Hif-1α; called Sima or Hifα in Drosophila), regulates a number of target genes that promote various aspects of cancer, including metabolism, angiogenesis, cell survival, drug resistance, and invasive motility (Wykoff et al., 2000; Carmeliet et al., 1998; Ryan et al., 1998; Pennacchietti et al., 2003; Ema et al., 1997; Semenza, 2003; Dang and Semenza, 1999). This evidence concerns the gene HIF1A and cancer.