In hepatocellular carcinoma, gastric cancer and lung cancer Jarid1a suppresses the expression of CDK inhibitors p21Cip1, P27Kip1 and P16Ink4a.32, 33, 34, 35 In addition, Jarid1b can repress the cell cycle inhibitor p21Cip1 in a variety of cell lines.36 In our study we found that the FaDu cell proliferation can also be inhibited upon the overexpression of Jarid1b. Here, KDM5A is linked to hepatocellular carcinoma.