Jaird1b has been reported to be overexpressed in breast cancer,7, 8, 9 lung cancer, bladder cancer,10, 11 colorectal cancer,12 prostate cancer13 and malignant melanoma.14 Jarid1b is upregulated in these cancers and required for cancer cell proliferation and tumor growth. The gene discussed is KDM5B; the disease is breast carcinoma.