TP53 and cancer: The p53 tumor suppressor protein acts as a major defense mechanism against cancer.25 Among its most distinctive features is its ability to elicit both apoptotic death and cell cycle arrest.26 Numerous p53 co-factors have been implicated in cellular processes, and the activation or suppression of these co-factors determines the fate of a cell.27, 28 Whether ANXA1 represents one of the p53 co-factors involved in the regulation of Bid expression and how ANXA1 might interact with p53 to coregulate Bid expression have yet to be determined.